Zollinger-Ellison Syndrome (ZES)

Marengo CIMS Hospital is dedicated to providing comprehensive healthcare services and fostering patient well-being. As part of our commitment to patient education, we have developed the Marengo CIMS Hospital Medical Encyclopedia—an invaluable online resource designed to empower patients with knowledge about various medical conditions, treatments, and preventive measures. This encyclopedia serves as a trusted and accessible repository of medical information, allowing patients to make informed decisions regarding their health and collaborate more effectively with healthcare professionals.


Zollinger-Ellison Syndrome (ZES) is a rare condition characterized by the presence of gastrin-secreting tumors called gastrinomas in the pancreas or duodenum. These tumors cause excessive production of stomach acid, leading to the development of gastric ulcers and other related complications. In the context of India, where healthcare accessibility and awareness are crucial, it is important to understand the signs, symptoms, classification, causes, diagnostic tests, treatment options, and disease prevention techniques associated with Zollinger-Ellison Syndrome.

Signs and Symptoms:

The most common symptoms of ZES include severe and recurrent abdominal pain, chronic diarrhea, heartburn, and unintended weight loss. These symptoms often persist despite the use of antacid medications and may worsen over time.

What is Zollinger-Ellison Syndrome?

Zollinger-Ellison Syndrome is a rare endocrine disorder characterized by the development of gastrinomas, which are tumors that produce excessive amounts of the hormone gastrin. Gastrin stimulates the stomach to produce acid, leading to hyperacidity and ulcers in the digestive tract.

Classification of Zollinger-Ellison Syndrome:

ZES can be classified into sporadic and hereditary forms. Sporadic ZES occurs randomly without any family history, while hereditary ZES is associated with a genetic condition called multiple endocrine neoplasia type 1 (MEN1).

Causes and Triggers:

The majority of sporadic ZES cases occur due to sporadic gastrinomas, which are not inherited or associated with any specific triggers. In hereditary ZES, mutations in the MEN1 gene play a role in the development of gastrinomas. MEN1 is an inherited condition that predisposes individuals to the development of various endocrine tumors.

Risk Factors with Examples:

The risk factors for ZES include:

1. Genetic predisposition: Individuals with a family history of MEN1 have an increased risk of developing hereditary ZES. For example, if a person’s parent or sibling has MEN1, they have a higher likelihood of developing ZES.

2. Age: ZES is typically diagnosed in individuals between the ages of 20 and 50, although it can occur at any age.

3. Gender: There is a slight male predominance in ZES cases.

Types of Zollinger-Ellison Syndrome:

ZES can be further classified based on the location and behavior of gastrinomas:

1. Sporadic Gastrinomas: These tumors occur sporadically in the pancreas or duodenum and are usually solitary.

2. Multiple Endocrine Neoplasia Type 1 (MEN1)-Associated ZES: This form of ZES is inherited and occurs in individuals with MEN1 syndrome. Gastrinomas in MEN1 patients can be multiple and affect various endocrine glands.

Diagnostic Tests and Treatment:

To diagnose ZES, several tests are employed, including:

1. Blood Gastrin Level Test: This test measures the level of gastrin in the blood. Elevated gastrin levels can indicate ZES.

2. Secretin Stimulation Test: Secretin, a hormone, is administered, and the response of gastrin levels is measured. In ZES, gastrin levels remain high even after secretin stimulation.

3. Imaging Tests: Imaging techniques such as computed tomography (CT) scans, magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS) are used to detect the presence and location of gastrinomas.

Treatment options for ZES include:

1. Medications: Proton pump inhibitors (PPIs) are commonly prescribed to reduce stomach acid production and alleviate symptoms.

2. Surgery: Surgical removal of gastrinomas is recommended, especially if they are large, causing complications, or if they are potentially cancerous.

3. Other Interventions: Additional interventions, such as radiofrequency ablation, embolization, or targeted therapy, may be considered depending on the individual case.

Complications of Zollinger-Ellison Syndrome:

If left untreated or inadequately managed, ZES can lead to severe complications, including bleeding ulcers, perforation of the stomach or intestine, and malabsorption of nutrients due to chronic diarrhea. These complications can significantly impact an individual’s quality of life and overall health.

Disease Prevention Techniques:

As ZES is primarily a genetic disorder, there are no specific prevention techniques. However, regular screening for individuals with a family history of MEN1 and early detection of gastrinomas through appropriate diagnostic tests can aid in timely treatment and better outcomes.

Zollinger-Ellison Syndrome (ZES) is a rare and complex condition that requires specialized medical care and expertise. In India, Marengo Asia Hospitals stands out as a leading healthcare provider, known for its multidisciplinary approach and state-of-the-art facilities. This article aims to explore how Marengo Asia Hospitals across India can effectively handle patients with Zollinger-Ellison Syndrome, providing comprehensive care and improving patient outcomes.

1. Specialized Medical Team:

Marengo Asia Hospitals boasts a highly skilled and experienced medical team consisting of gastroenterologists, endocrinologists, surgeons, radiologists, and pathologists. These specialists collaborate to provide a multidisciplinary approach in diagnosing and treating ZES, ensuring accurate evaluation and personalized care for each patient.

2. Advanced Diagnostic Facilities:

Marengo Asia Hospitals hospitals are equipped with advanced diagnostic facilities, including state-of-the-art imaging technologies such as computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS). These diagnostic tools help identify the presence, location, and size of gastrinomas, enabling precise treatment planning.

3. Comprehensive Diagnostic Testing:

The hospitals within Marengo Asia Hospitals offer a range of diagnostic tests specifically designed for ZES, including:

a. Blood Gastrin Level Test: This test measures the level of gastrin in the blood, aiding in the diagnosis of ZES.

b. Secretin Stimulation Test: By administering secretin and monitoring the response of gastrin levels, this test helps confirm ZES and assess the functionality of gastrinomas.

c. Genetic Testing: In cases of suspected hereditary ZES associated with multiple endocrine neoplasia type 1 (MEN1), genetic testing plays a crucial role. Marengo Asia Hospitals hospitals offer comprehensive genetic testing services to identify MEN1 mutations.

4. Individualized Treatment Plans:

Once a diagnosis of ZES is confirmed, Marengo Asia Hospitals develops personalized treatment plans tailored to each patient’s specific needs. Treatment options may include:

a. Medications: Skilled gastroenterologists and endocrinologists prescribe proton pump inhibitors (PPIs) to manage excessive stomach acid production and alleviate symptoms.

b. Surgical Intervention: The network’s expert surgical team evaluates the feasibility of surgical removal of gastrinomas, considering factors such as tumor size, location, and potential for malignancy.

c. Interventional Radiology: Interventional radiologists may employ techniques such as radiofrequency ablation or embolization to treat gastrinomas that are not amenable to surgical resection.

5. Post-treatment Care and Rehabilitation:

Marengo Asia Hospitals recognizes the importance of post-treatment care and rehabilitation in the management of ZES. They offer comprehensive follow-up care, including regular monitoring, imaging scans, and laboratory tests to ensure early detection of any recurrence or complications.

6. Patient Support Services:

The network emphasizes the provision of holistic care, offering patient support services that address the emotional, psychological, and social aspects of living with ZES. This includes counseling, support groups, and educational resources to help patients and their families cope with the challenges associated with the condition.

Marengo Asia Hospitals stands at the forefront of managing Zollinger-Ellison Syndrome in India, employing a multidisciplinary approach and offering comprehensive care. By combining accurate diagnosis, customized treatment plans, surgical expertise, nutritional support, and patient education, the hospitals within the network provide the necessary tools for effective management of ZES. Marengo Asia Hospitals remains committed to delivering high-quality healthcare, ensuring the best possible outcomes for individuals living with Zollinger-Ellison Syndrome across India.


Contact Us

Marengo CIMS Hospital
Off Science City Road, Sola, Ahmedabad – 380060
Gujarat, INDIA

24×7 Helpline +91 70 69 00 00 00
Phone: 079 4805 1200 or 1008
+91 79 2771 2771 or 72
Fax: +91 79 2771 2770
Mobile: +91 98250 66664 or +91 98250 66668
Ambulance: +91 98244 50000
Email: info@cims.org