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Research Activities

Research Activities


PHARMACOLOGICAL AGENT

Sr.
No.
Investigational ProductIndicationStudy
Phase
Status
1Allogenic Stem cellPost MIIOngoing
2Oral Anti platelet drugAcute Coronary
Syndrome
IIOngoing
3Oral Anti Thrombotic drugAcute Coronary
Syndrome
IICompleted with Highest
enrollment in India
4Oral Anti Coagulant drugAcute Coronary
Syndrome
IICompleted with Highest
enrollment in India
5ACE Inhibitor in ChildrenPaediatric HypertensionIICompleted
6Anti hyperlipidemic drugDyslipidemiaIICompleted
7Endothelin AntagonistPulmonary HypertensionIIIOngoing
8Anti hyperlipidemic drugChronic Coronary Artery
Heart Disease
IIIOngoing with Highest enrollment
in India
9Oral Anti platelet drugAcute Coronary
Syndrome
IIIOngoing with Highest enrollment
in India
10Oral Anti platelet drug (R)Non-Valvular Atrial
Fibrillation
IIIOngoing
11Oral Anti platelet drug (A)Non-Valvular Atrial
Fibrillation
IIIOngoing
12Oral Anti Coagulant drugSecondary prevention of
venous thromboembolism
IIIOngoing
13SC Anti Coagulant drugAtrial FibrillationIIIOngoing
14Prostacyclin analoguePulmonary Arterial
Hypertension
IIIOngoing
15Anti Anginal drugStable angina pectorisIIIOngoing
16Haematopoetic agentHeart Failure with anemiaIIIOngoing
17Oral Anti platelet drug (R)Medically ill patients at
risk of DVT
IIIOngoing
18IV Anti platelet drugPercutaneous Coronary
Intervention (PCI)
IIIEnrolment completed.
19Oral Anti platelet drugSTEMI / NSTEMIIIIEnrolment completed.
20IV GPIIb/ IIIa drugNSTEMIIII bEnrolment completed. 4th highest
enrolment in world
21IV AbciximabPercutaneous Coronary
Intervention (PCI)
IIICompleted
22Oral Anti Coagulant drugNon-Valvular Atrial
Fibrillation
IIICompleted
23Angiotenion Receptor BlockerPaediatric HypertensionIIICompleted
24Prostacyclin InfusionPulmonary Arterial
Hypertension
IIICompleted
25OASIS 5 (LMWH)Acute Coronary
Syndrome
IIIStudy completed, 100% Follow up.
One of the highest enrollments in
the country.
26OASIS 6 (LMWH)Acute Myocardial
Infarction
IIIEnrollment completed.100%
Follow up of enrolled patients.
27EXTRACT TIMI-25 (LMWH)Acute Coronary
Syndrome
IIIStudy completed, 100% Follow up
28SC Anti Coagulant drugPercutaneous Coronary
Intervention (PCI)
IVOngoing
29Aliskiren (RESILAZ)Essential HypertensionIVOngoing
30POLYCAPPatient at atleast one CV
risk
IVCompleted
31Oral Antiplatelet drugAcute Coronary
Syndrome
IVCompleted
32IV Anti Coagulant drugPercutaneous Coronary
Intervention (PCI)
IVCompleted
33Newer Generation StatinHyperlipidemiaIIICompleted
34Tirofiban GPIIb/ IIIa InhibitorPercutaneous Coronary
Intervention (PCI)
IVCompleted
35Newer Generation Statin –
Pitavastatin
Hyperlipidemia (PCI)IVCompleted
36Oral LpPLA2 inhibitorAcute Coronary
Syndrome
IIIOngoing
37PPARS alfa/gamaagnoistAcute Coronary
Syndrome & Type 2
Diabetes mellitus
IIIOngoing
38Endevar Resolute Stent (38mm)Coronary Artery DiseaseIVOngoing
39Oral Anticoagulant DrugAcute Coronary
Syndrome
IIIOngoing
40Oral Factor Xa InhibitorAcute Coronary
Syndrome
IIOngoing
SURGERY
1Comparison of CABG and
optimum medical therapy
Coronary Artery DiseaseIVFollow up Ongoing
INVESTIGATIONAL/ MARKETED DEVICE
1Neovasc: Coronary Sinus StentCoronary Artery Disease.FIMCompleted
2Papirus:Implantable Ultrasonic deviceHeart FailureFIMCompleted
3Rotational Atherectomy DeviceStable AnginaFIMCompleted
4Thrombosuction CatheterPrimary Angioplasty in MIPre MarketingCompleted
5Zotarolimus-Eluting Coronary
Stent
Percutaneous Coronary
Intervention (PCI)
IVEnrolment completed, with Highest
in India
6CYPHER Select Sirolimus-eluting
Coronary Stent
Percutaneous Coronary
Intervention (PCI)
IVEnrolment completed
7Randomized DES studyPercutaneous Coronary
Intervention (PCI)
IVEnrolment completed, with Highest
in India
8Paclitaxel-Eluting Coronary StentPercutaneous Coronary
Intervention (PCI)
IVCompleted
9E CYPHER RegistryPercutaneous Coronary
Intervention (PCI)
IVStudy completed, with highest
enrolment
10Implantable Cardiac DeviceArrythmiasIVOngoing
11Digital pacemaker RegistryArrythmiasIVCompleted
12ABT-578 Drug Eluting coronary
Stent
Percutaneous Coronary
Intervention (PCI)
IVStudy completed, with highest
enrolment
13Percu Serge™ Gaurdwire (RUBY)Percutaneous Coronary
Intervention (PCI)
IVCompleted
PROJECTS UNDERTAKEN BY CCC FOR INDEPENDENT INVESTIGATORS
1Effect of Folate treatment on Homocystenemia in cardiac patients: A prospective study.
2Reversal of Slow or no reflow during Percutaneous Transluminal Coronary Angioplasty during intracoronaryboluses of Adenosine and Sodium Nitroprusside in combination.
3Pharmacoepidemiology and Risk factors of Hypertension in western Gujarat.
4Effect of statins and their combination with fenofibrate in patients undergoing percutaneous transluminal coronary angioplasty.
5Effect of Niacin treatment on hyperlipoproteinemia in coronary artery disease patients.
6Effect of combinations of various intracoronary drugs in no-reflow patients undergoing percutaneous coronary intervention.
7Comparison of drug eluting stent with conventional S7 Stent.
8The use of distal protection device (DPD) during angioplasty and to compare the acute long-term events of intracoronary injections of drugs in no-reflow as compared to distal protection device.
9Assessment of risk factors for coronary artery disease.
10High prevalence of renal artery stenosis in hypertensive patients with triple vessel coronary artery disease: recommendation for simultaneous renal
11Arteriogram for earlier intervention.
12Effect of pioglitazone and its combination with statins in CAD patients with hyperinsulinemia.
13Safety and Efficacy of High Dose Intracoronary bolus of tirofiban in patients with AMI undergoing Primary / Rescue coronary angioplasty.
14Short term and Long term effect of Metoprolol XL on PAP in patients with CHF using first in human implantable device responding to ultrasonic signal.
15Comparison of Short Term and Long term Effect of Metoprolol XL versus Carvedilol on Pulmonary artery Pressure in patients with chronic Heart Failure using first in human implantable device responding to
ultrasonic signal.
16First in human CT angiography images of “Pulmonary artery Stenting with a transducer device” in patients with heart failure.
17Effects of Cardiac Rehabilitiation on PA pressure in patients with Chronic Heart Failure using first in human implantable device responding to ultrasonic signal.
18How to treat Heart Failure? Is there any difference after ambulatory PA pressure monitoring.
19Diurnal variation in PA pressure measured using First in Human implantable device responding to ultrasonic signals.
20Association of BNP and PA pressure monitored through first in human implantable device in patients with HF.
21Acute effects on Pulmonary artery pressure, on rest and after exercise in patients in patients with heart failure (EF<35%) using first in human implantable device for PAP responsing to ultrasonic signals.
22Comparison of Chronical HF device (Medtronic) versus Remon CHF system (Remon) for ambulatory PAP measurement in patients with heart failure.
23First in human pilot study of safety and efficacy of Neovasc Reducer Implant in the treatment of ischemic heart disease by controlled narrowing of the coronary sinus, in patients with No-Options.
24Evaluation of Coronary arterial system and collaterals subsequent to first in human Neovasc Reducer TM Implantation in Coronary Sinus in “No Options” patients using 40 Slice Multi-detector Computed Tomography
25Non invasive Visualization of first in human Neovasc Reducer TM Implant in Coronary Sinus using 40 Slice Multi-detector Computed Tomography.
26Effect of Coronary Sinus Retroperfusion Stent (Neovasc Reducer®) on angiogenic, inflammatory and genetic markers.
RESEARCH PAPERS
1Ovalum CiTopTM: A Novel Guidewire for crossing Chronic Total Occlusion in Coronary Artery Disease patients – First-in-Man Experience. Euro Intervention Supplement E Volume 5 May 2009.
2Effect of Metoprolol CR/XL on Pulmonary Artery Pressure in Chronic Heart Failure Patients Assessed by an Implanted Ultrasonic Device with Special Emphasis on Diurnal Variation and Exercise Capacity;Indian Heart Journal Volume 61 No. 1, January-February 2009.
3Intracoronary boluses of adenosine and sodium nitroprusside in combination reverse slow/no-reflow during angioplasty: a clinical scenario of ischemic preconditioning. Can J Physiol Pharmacol. 2007 Mar-Apr; 85(3-4):476-82.
4Coronary Sinus Reducer-Stent for the Treatment of Chronic Refractory Angina Pectoris: A prospective, open label, multi-center safety feasibility first-in-man study. J Am. Coll. Cardiol 2007; 49:1783-1789.
5Wireless acoustic communication with a miniature pressure sensor in the pulmonary artery for disease surveillance and therapy of patients with congestive heart failure. J Am Coll Cardiol 2007; 49:784-9.
6First–In-Man Study: Effect of Metoprolol CR/XL Uptitration on pulmonary artery pressure and its variation in chronic heart failure monitored non-invasively using an implanted device responding to ultrasonic signals. Indian Heart J 2009
7Efficacy of Percusurge in Acute Myocardial Infarction patients undergoing Revascularization with a special emphasis on Procedural time. Ind Heart J 2008.
8Beneficial Effects of Addition of Fenofibrate to Statin Therapy in Patients with Acute Coronary Syndrome after Percutaneous Coronary Interventions. Exp Clin Cardiol 2007, 12:91-6.
REVIEW ARTICLES
1Investigational Treatments and Future Directions in Heart Failure. Cardiol Today 2007; 12:96-103.
2Basics of Stem Cell Therapy in Heart Failure. Cardiol Today 2007; 12: 104-114
3Homocysteine and Coronary Artery Disease. Ind J Pharm Sci 2004; 66: 595-601
4Molecule of the Millennium: Bosentan in Primary Pulmonary Hypertension.Ind J Pharmacol 2004; 36: 118
5Prevalence of Hyperhomocysteinemia in Western Indian Population with or without Coronary Artery Disease.Ind J Cardiol 2003; 6: 54-58
6HPCR Guidelines for Heart Failure Therapeutics. Ind Heart J 2000; 52: 6
7Ischemic Heart Disease Endothelial Dysfunction. Ind Heart J 2000; 52: 6
8Gujarat Earthquake – A Cardiologist’s Perspective. Ind Heart J 2002
9Use of Abciximab (Reopro): In High Risk Coronary Artery Disease Patients during angioplasty and Stents. Guj Med J 1999; 56: 1
ABSTRACTS AND PRESENTATIONS IN INTERNATIONAL AND NATIONAL CONFERENCES
1Long Term Safety, Angina Relief and Improvement in Quality of Life in Patients with Refractory Angina Treated with the Neovasc Coronary Sinus Reducer. Presented at ACC 2009
2First In Man Assessment Of Orbital Atherectomy System In Treating De Novo Calcified Coronary Lesion (ORBIT I). Presented at ACC 2009
3Randomized, Multi-centric, Open label study to evaluate safety & efficacy of Faximab, A biosimailar Abciximab in Indian patients undergoing percutaneous coronary intervention; Submitted to Indian Heart Journal in August 2008.
4Safety & efficacy of indigenously developed and manufactured Bivalirudin in moderate/high risk indian patients undergoing percutaneous coronary intervention; Bivaflow registry; Indian Heart J: July-Aug, Volume 60, No.4.
5First-in-man: Effect of Metoprolol CR/XL uptitration on pulmonary artery pressure and its variation in chronic heart failure monitored non-invasively by an implanted device using ultrasonic signals. Presented at European Society of Cardiology Congress, September 2007.
6Association Between the White Blood Cell Count and Occurrence of Slow or No Reflow Phenomenon in Patients with Acute Coronary Syndromes in the Coronary Interventional Era. Presented at Annual Conference of The Cardiological Society of India (CSI-2006) Ind Heart J 2006; 58:436
7Incidences and Clinical Characteristics of No Reflow after Percutaneous Coronary Interventions in High Risk Asian Indian Patients. Presented at Annual Conference of The Cardiological Society of India (CSI-2006) Ind Heart J 2006; 58:418
8Initial Clinical Experience with Bivalirudin as an Anticoagulant during Percutaneous Coronary Interventions in Asian Indian patients. Presented at Annual Conference of The Cardiological Society of India (CSI-2006) Ind Heart J 2006; 58:435-6
9Prospective randomized study of Percusurge in acute myocardial infarction patients undergoing revascularization with a special emphasis on procedural time: A two year follow-up. Presented at Annual Conference of The Cardiological Society of India (CSI-2006) Ind Heart J 2006; 58:417-8
10High prevalence of renal artery stenosis in hypertensive patients with triple vessel coronary artery disease: recommendation for simultaneous renal arteriogram for earlier intervention. Presented at Annual Conference of The Cardiological Society of India (CSI-2006) Ind Heart J 2006; 58:454
11First-In-Man: Direct Comparison of Conventional Coronary Sinus Angiography and CT Angiography for Visualization and Sizing of Coronary Sinus. Presented at International Symposium of Transcatheter Cardiovascular Therapeutics (TCT) 2006, Washington DC
12First-In-Man: Multi-Slice CT Angiography Visualization of an Innovative First-in-Man Coronary Sinus Reducer Stent in Patients with Refractory Angina. Presented at International Symposium ofTranscatheter Cardiovascular Therapeutics (TCT) 2006, Washington DC
13First-In-Man: Measurement of diurnal variation in Pulmonary Artery Systolic and Diastolic Pressure in Heart Failure Patients Using an Innovative Implantable Device Responding to Ultrasonic Signals. Eur Heart J 2006; 27 (Abstract Supplement): 485
14First–In-Man: Non-Invasive Measurement of Variation in Pulmonary Artery Pressure Following Exercise in Heart Failure Patients Using an Innovative Implantable Device Involving Acoustic Telemetry. Eur Heart J 2006; 27 (Abstract Supplement): 949
15First-In-Man: Effect of Metoprolol CR/XL on Exercise Capacity and Subsequent Variation in Pulmonary Artery Pressure in Heart Failure Patients Using an Innovative Implant Involving Acoustic Telemetry. Eur Heart J 2006; 27 (Abstract Supplement): 949
16First-In-Man Non-Invasive Monitoring of Pulmonary Artery Pressure from an Implantable Device Using Acoustic Telemetry: A One Year Follow-Up Data. Eur Heart J 2006; 27 (Abstract Supplement): 202
17First-In-Man: Comparison of Impressure Device Measuring Pulmonary Artery Pressure Non-invasively with Conventional Contrast Echocardiography in Congestive Heart Failure. Eur Heart J 2006; 27 (Abstract Supplement): 202
18First-In-Man study: Effect of Metoprolol CR/XL on Diurnal Variation in Pulmonary Artery Pressure Assessed< Non-invasively Using an Innovative Implantable Device Responding to Ultrasonic Signals.Eur Heart J 2006; 27 (Abstract Supplement): 344
19Intracoronary Boluses of Adenosine and Sodium Nitroprusside Combination Reverses Slow/No Reflow During Angioplasty: A Clinical Scenario of Experimental Preconditioning. Oral and Poster presentation at the Young Investigator’s Awards Competition, American College of Cardiology Conference, March 2006
20Efficacy of PercuSurge GuardWire system in Acute Myocardial Patients Undergoing Primary/Rescue PCI with a special emphasize on procedural time. Indian Heart Journal, August 2008
21First-In-Man: PAPIRUS – Monitoring Pulmonary artery Pressure by Implantable device responding to Ultrasonic Signals. Oral presentation at the Late breaking Clinical Trials Session at ACC-i2 summit,American College of Cardiology Conference, March 2006
22First-In-Man Implanted Device in Pulmonary Artery Using Acoustic Telemetry Based on Non-invasive Ultrasound Activation and Communication. American College of Cardiology Conference, March 2006
(e-Poster Presentation)
23Effect of Metoprolol XL on Pulmonary Artery Pressure in Patients with Heart Failure Measured Using First-In-Man Implantable Device Responding to Ultrasonic Signal. J Am Coll Cardiol 2006; 47: 310A.
24Effect of Metoprolol XL on Diurnal Variation in Pulmonary Artery Pressure Measured Non-invasively Using First-In-Man Implant Responding to Ultrasonic Signals. J Am Coll Cardiol 2006; 47: 370A
25First-In-Man: Coronary Sinus Narrowing with a Reducer Stent – A Possible Alternative Percutaneous Treatment for Patients with Refractory Angina. J Am Coll Cardiol 2006; 47: 17B
26Efficacy of PercuSurge GuardWire system in Acute Myocardial Patients Undergoing Primary/Rescue PCI. Oral Presentation at Joint International Conference of ISHR and IACS, Jan 2005, Gujarat, India
27Associations of White Blood Cell Count with the Occurrence of Slow/No reflow in Acute Coronary Syndrome Patients Undergoing PCI. Poster presentation at Joint International Conference of ISHR and IACS, Jan 2005, Gujarat, India
28Beneficial Effects of Distal Protection Device in Reducing the Use of Intracoronary Vasodilators and Glycoprotein IIb/IIIa Receptor Antagonists during Percutaneous Coronary Interventions. Presented at Annual Conference of Society of Cardiovascular Angiography and Interventions (SCAI), San Diego, May 2004. Catheter Cardiovasc Interven 2004; 62: pg 90
29Revascularization in Acute Myocardial Infarction Using PercuSurge in Distal Protection (RAPID). Presented at Annual Conference of Society of Cardiovascular Angiography and Interventions (SCAI), San Diego, May 2004. Catheter Cardiovasc Interven 2004; 62: pg 116
30Improvement in MACE by Sequential Administration of Boluses of Intracoronary Adenosine and Sodium Nitroprusside during Percutaneous Coronary Interventions. Presented at Annual Conference of Society of Cardiovascular Angiography and Interventions (SCAI), San Diego, May 2004. Catheter Cardiovasc
Interven 2004; 62: pg 130-131
31Improvement in MACE by Sequential Administration of Boluses of Intracoronary Adenosine and Sodium Nitroprusside during Percutaneous Coronary Interventions. European Society of Cardiology, 2004, Munich, Germany
32Renal Artery Stenting is Safe and Effective Modality of Treatment on Mid-term Follow-up. Poster presented at 56th Annual Conference of The Cardiological Society of India (CSI) at Bangalore, December 2004
33Increased Lipoprotien (a) as a Strong Risk Factor for Coronary Artery Disease and the Effect of Niacin Amongst Indians. 56th Annual Conference of The Cardiological Society of India (CSI) at Bangalore, December 2004
34Effect of Statins in Combination with Fenofibrate in Patients after Percutaneous Transluminal Coronary Angioplasty. Ind J Pharmacol 2004; 36(2): pg 113
35Pharmaco-epidemiology and Risk Factors of Hypertension in Western Gujarat. Ind J Pharmacol 2003:35(4), pg. 277.
36Acute Results and Intermediate Term Follow-up of PCI with Cardio-protection by Balloon Occlusion Distal Protection Device. Ind Heart J 2002; 54: 561-568
37Reversal of Slow-Flow or No-Reflow During PTCA Using Boluses of IC Adenosine and Sodium Nitroprusside, in Combination. J Am Coll Cardiol 2003, Suppl.A to 54:561-568
INTERNATIONAL AND NATIONAL SLIDE PRESENTATIONS
1Orbital Atherectomy: Preliminary Experience in Calcific Coronary Artery Disease: C3 Capital Cardiovascular Conference, U.S.A. , Jun 2009
2Ovalum CiTop: FIM Results and Early Clinical Experience: Chronic Total Occlusion Summit (CTO 2009), U.S.A., Feb 2009
3First-In-Man Results with the Ovalum CiTopTM ExPander TM Guidewire in Chronic Total Occlusions:Innovations in Cardiovascular Interventions , Israel, Dec 2008
4Orbital Atherectomy for de novo Calcified Coronary Lesions: The ORBIT I FIM Study: Transcatheter Cardiovascular Therapeutics, Washington DC, U.S.A, Oct 2008
5Cardiac Pressure Monitoring Devices: Device-based Approaches for Heart Failure II: Emerging Interventional Technologies (REMON): Transcatheter Cardiovascular Therapeutics, Washington DC, U.S.A, Oct 2008
6Utility and Development of Novel Devices for CTO Applications: The Ovalum CiTop Guidewire System: FIM Coronary CTO Results: Transcatheter Cardiovascular Therapeutics, Washington DC, U.S.A, Oct 2008
7Revisiting Blunt Microdissection Topic: First-in-Man Results with the Ovalum CiTop Guidewire System:Chronic Total Occlusion Summit(CTO 2008): New York, Feb 2008
8New frontiers in Chronic Total Occlusions Topic: CiTopTM Guidewire – Innovations in Cardiovascular Interventions, Israel, Dec 2007
9Cardiac Monitoring Devices for CHF – Transcatheter Cardiovascular Therapeutics 2007, Washington, Oct 2007
10The Ovalum CiTop Guide Wire System – Transcatheter Cardiovascular Therapeutics 2007,Washington, Oct 2007
11Using the REMON Pressure Device: One year Follow-up — Innovations in Cardiovascular Interventions, Israel, Dec 2006
12Global Device Evaluation: Can interventions in India Lead the Way —Innovations in Cardiovascular Interventions, Israel, Dec 2006
13Management of Complex Dyslipidemias — Annual conference of The Cardiology Society of India, Dec 2006
14Heart Failure: Triumphs and Tribulations – 2006 — Annual conference of The Cardiology Society of India, Dec 2006
15PAPIRUS I: One Year Follow-Up of a Novel Pulmonary Artery Implant (and PAPIRUS II Status)—Transcatheter Cardiovascular Therapeutics, Oct 2006
16Intracoronary Adenosine and Nitroprusside for Slow/No Reflow: From Experimental Preconditioning to Clinical Utility — Transcatheter Cardiovascular Therapeutics, Oct 2006
17PAPIRUS – Monitoring Pulmonary Artery Pressure by Implantable Device Responding to Ultrasonic Signals — Annual conference of American College of Cardiology, March 2006
18Intracoronary Boluses Of Adenosine and Sodium Nitroprusside Combination Reverses Slow/No Reflow During Angioplasty: A Clinical Scenario of Experimental Preconditioning — Annual conference of American College of Cardiology, March 2006
19First-In-Man Pilot Study using the REMON Ultrasonic Intravascular Sensor to Measure Pulmonary Artery Pressure — Transcatheter Cardiovascular Therapeutics, 2005.
20Preliminary Clinical Experience with the NEOVASC Coronary Sinus Reducer Stent — Transcatheter Cardiovascular Therapeutics, 2005
CHAPTER IN BOOKS
1Shah HD, Parikh KH, Goyal RK. Recent Trends in Antiplatelet Therapy for Acute Coronary Syndromes: Glycoprotein IIb/IIIa receptor antagonists: In Pharmacotherapy of Heart Failure by S K Gupta 2005; 102:22
2Parikh KH, Shah HD. Stem Cell Therapy in ACS: Type, timing and promise: In The Post Graduate Medicine-2006 (In Press, Scheduled Feb 2006)
3Parikh KH, et al., Development of Group Practice in Cardiology, Financial planning and Research and development: CSI Book 2005
4Parikh KH, Shah HD, et al., Stem cell Therapy in ACS; Type, Timing and Promise: AAPI Book, 2006
5Mehta K N, Parikh K H, Chag MC, Shah U G, Baxi H A, Chandarana A H, Naik A M, Goyal R K, Effect of Folate Treatment on Homocysteinemia in Cardiac Patients: A Prospective Study: Indian Journal of Pharmacology;2005;Vol 37:13-17
6Parikh KH, Chag MC, Shah UG, Baxi HA, Chandarana AH, Naik AM, Shah HD, Shah JN, Goyal RK; Beneficial effects of addition of fenofibrate to statins In acute coronary syndrome patients undergoing Percutaneous coronary interventions.: World heart Journal