Renal Cell carcinoma ( RCC)

Marengo CIMS Hospital is dedicated to providing comprehensive healthcare services and fostering patient well-being. As part of our commitment to patient education, we have developed the Marengo CIMS Hospital Medical Encyclopedia—an invaluable online resource designed to empower patients with knowledge about various medical conditions, treatments, and preventive measures. This encyclopedia serves as a trusted and accessible repository of medical information, allowing patients to make informed decisions regarding their health and collaborate more effectively with healthcare professionals.


Renal Cell Carcinoma (RCC) is a type of kidney cancer that predominantly affects the cells lining the small tubes within the kidney. It is the most common type of kidney cancer in adults, accounting for approximately 90% of cases. In India, RCC poses a significant health concern, and understanding its signs, symptoms, classification, causes, risk factors, diagnostic tests, treatments, and prevention techniques is crucial in combatting this silent threat.

Signs and Symptoms:

In its early stages, RCC often exhibits no symptoms, making it difficult to detect. However, as the disease progresses, certain signs and symptoms may manifest, including:

1. Blood in the urine (hematuria): One of the most common indications of RCC is the presence of blood in the urine, which may appear pink, red, or cola-colored.

2. Lower back pain or flank pain: RCC may cause persistent pain in the lower back or sides, just below the ribs.

3. Unexplained weight loss: Rapid and unexplained weight loss can be a symptom of RCC, often accompanied by loss of appetite and fatigue.

4. Fatigue and weakness: RCC may lead to persistent fatigue and a general feeling of weakness.

5. Palpable mass or lump: In some cases, a mass or lump may be felt in the abdomen or lower back.

What is RCC?

Renal Cell Carcinoma (RCC) is a type of kidney cancer that originates in the lining of the small tubes (tubules) within the kidney. It arises when normal cells in the kidney undergo genetic mutations, leading to uncontrolled cell growth and the formation of a malignant tumor.

How is RCC Classified?

RCC can be classified into several subtypes, including:

1. Clear Cell RCC: This is the most common subtype, accounting for approximately 70-80% of all RCC cases. Clear cell RCC is characterized by clear cytoplasm within the cancerous cells.

2. Papillary RCC: This subtype accounts for around 10-15% of RCC cases. It is characterized by the presence of finger-like projections (papillae) within the cancerous cells.

3. Chromophobe RCC: This subtype accounts for approximately 5% of RCC cases. Chromophobe RCC is characterized by large cells with irregular borders and pale or eosinophilic cytoplasm.

4. Collecting Duct RCC: This is a rare and aggressive subtype, accounting for less than 1% of RCC cases. It arises from the collecting ducts of the kidney.

Causes and Triggers:

The exact cause of RCC is still unknown. However, certain risk factors and triggers have been identified, including:

1. Smoking: Cigarette smoking increases the risk of developing RCC.

2. Obesity: People who are overweight or obese have a higher risk of developing RCC.

3. Hypertension: Chronic high blood pressure is associated with an increased risk of RCC.

4. Family history: A family history of kidney cancer or certain inherited genetic conditions, such as Von Hippel-Lindau disease, increases the risk of developing RCC.

5. Exposure to certain chemicals: Occupational exposure to certain chemicals, such as asbestos, cadmium, and organic solvents, may increase the risk of RCC.


Diagnostic Tests and Treatments:

1. Imaging tests: Imaging tests such as ultrasound, CT scan, and MRI are used to detect and evaluate the extent of RCC.

2. Biopsy: A biopsy involves the removal of a small tissue sample from the kidney to confirm the diagnosis of RCC and determine its specific subtype.

3. Surgery: The primary treatment for localized RCC is surgery, which may involve removing a part of the kidney (partial nephrectomy) or the entire kidney (radical nephrectomy).

4. Targeted therapy: Targeted therapy uses drugs that specifically target cancer cells or their supporting structures, inhibiting their growth and spread.

5. Immunotherapy: Immunotherapy enhances the body’s immune system to recognize and destroy cancer cells.

Complications of RCC and Prevention Techniques:

Complications of RCC may include the spread of cancer to other organs, recurrence of the disease, and the development of metastases. To prevent RCC and reduce the risk, the following techniques are recommended:

1. Quit smoking: Smoking cessation reduces the risk of developing RCC.

2. Maintain a healthy weight: Adopting a balanced diet and engaging in regular physical activity can help maintain a healthy weight and reduce the risk of RCC.

3. Control blood pressure: Regular monitoring and management of hypertension can lower the risk of RCC.

4. Limit exposure to chemicals: Minimize exposure to harmful chemicals, such as asbestos and organic solvents, by following safety guidelines at work.

Renal Cell Carcinoma (RCC) poses a significant health challenge in India, requiring specialized medical care and comprehensive treatment approaches. Marengo Asia Hospital, a renowned healthcare institution with a wide presence across India, is well-equipped to handle patients with RCC. With its state-of-the-art facilities, experienced medical professionals, and patient-centric approach, Marengo Asia Hospital is dedicated to providing the highest quality care to individuals affected by RCC.

Comprehensive Diagnostic Capabilities:

Marengo Asia Hospitals boasts cutting-edge diagnostic capabilities, enabling accurate and timely detection of RCC. The Hospitals offer a range of diagnostic tests, including:

1. Imaging Tests: Advanced imaging techniques such as ultrasound, computed tomography (CT) scan, magnetic resonance imaging (MRI), and positron emission tomography (PET) scan are available to visualize the kidneys and assess the extent of the disease.

2. Biopsy: Expert pathologists perform renal biopsies to obtain tissue samples, allowing precise determination of RCC type and subtype, which aids in formulating personalized treatment plans.

Multidisciplinary Treatment Approach:

Marengo Asia Hospitals adopts a multidisciplinary approach to RCC treatment, ensuring that patients receive comprehensive care from a team of specialists, including urologists, medical oncologists, radiation oncologists, and pathologists. This collaborative approach allows for individualized treatment plans tailored to each patient’s unique condition.

1. Surgical Expertise: The hospitals within Marengo Asia Hospitals have highly skilled urologists who specialize in minimally invasive surgical techniques. These include laparoscopic and robotic-assisted surgeries, which offer advantages such as smaller incisions, reduced pain, and faster recovery times. Surgical options range from partial nephrectomy for localized tumors to radical nephrectomy for more advanced cases.

2. Targeted Therapy: Marengo Asia Hospitals provides access to targeted therapy, which involves the use of specific drugs that target cancer cells’ molecular abnormalities. These medications help inhibit tumor growth and spread, minimizing the impact on healthy cells.

3. Immunotherapy: The hospitals within the network also offer immunotherapy, a revolutionary treatment option that harnesses the body’s immune system to identify and attack cancer cells. Immunotherapy has shown promising results in extending survival rates and improving overall outcomes in RCC patients.

4. Radiation Therapy: When required, Marengo Asia Hospitals utilizes advanced radiation therapy techniques, such as intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), to precisely target and destroy cancerous cells while minimizing damage to surrounding healthy tissue.

Supportive Care and Rehabilitation:

Recognizing the importance of holistic patient care, Marengo Asia Hospitals provides comprehensive supportive care and rehabilitation services for individuals with RCC. This includes:

1. Pain Management: Expert pain management specialists work closely with patients to alleviate pain and discomfort associated with RCC and its treatments.

2. Psychosocial Support: Dedicated counselors and support groups are available to address the emotional and psychological challenges faced by RCC patients and their families, providing much-needed guidance and support throughout the treatment journey.

3. Rehabilitation Services: The hospitals offer rehabilitation programs to help patients regain strength, mobility, and overall well-being after surgery or other treatments. These programs include physical therapy, occupational therapy, and nutritional counseling.

Clinical Trials and Research:

Marengo Asia Hospitals actively participates in clinical trials and research studies aimed at advancing RCC treatment options. By being at the forefront of medical research, the hospitals can offer patients access to innovative therapies and the latest advancements in RCC management.

Marengo Asia Hospitals stands as a pillar of hope for patients battling RCC across India. With its advanced diagnostic capabilities, multidisciplinary treatment approach, supportive care services, and commitment to research, the network ensures that patients receive the highest standard of care throughout their RCC journey. By combining expertise, cutting-edge technology, and compassion, Marengo Aisa Hospitals plays a vital role in empowering patients, improving outcomes, and ultimately combating RCC in India.


Contact Us

Marengo CIMS Hospital
Off Science City Road, Sola, Ahmedabad – 380060
Gujarat, INDIA

24×7 Helpline +91 70 69 00 00 00
Phone: 079 4805 1200 or 1008
+91 79 2771 2771 or 72
Fax: +91 79 2771 2770
Mobile: +91 98250 66664 or +91 98250 66668
Ambulance: +91 98244 50000